A Truncated Form of IKKα Is Responsible for Specific Nuclear IKK Activity in Colorectal Cancer
نویسندگان
چکیده
منابع مشابه
A truncated form of IKKα is responsible for specific nuclear IKK activity in colorectal cancer.
Nuclear IKKα regulates gene transcription by phosphorylating specific substrates and has been linked to cancer progression and metastasis. However, the mechanistic connection between tumorigenesis and IKKα activity remains poorly understood. We have now analyzed 288 human colorectal cancer samples and found a significant association between the presence of nuclear IKK and malignancy. Importantl...
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ژورنال
عنوان ژورنال: Cell Reports
سال: 2012
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2012.08.028